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Article

Pleiotropy-Based Decomposition of Genetic Risk Scores: Association and Interaction Analysis for Type 2 Diabetes and CAD.

American journal of human genetics - 7 May 2020

Chasman Daniel I, Giulianini Franco, Demler Olga V, Udler Miriam S

Abstract excerpt

Genetic risk for a disease in the population may be represented as a genetic risk score (GRS) constructed as the sum of inherited risk alleles, weighted by allelic effects established in an independent population. While this formulation captures overall genetic risk, it typically does not address risk due to specific biological mechanisms or pathways that may nevertheless be important for interpretation or...

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PMID: 32302534
DOI: 10.1016/j.ajhg.2020.03.011
PMCID: PMC7212269

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