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Article

Dance with the Devil: Stress Granules and Signaling in Antiviral Responses

4 Sept 2020

Abstract excerpt

Cells have evolved highly specialized sentinels that detect viral infection and elicit an antiviral response. Among these, the stress-sensing protein kinase R, which is activated by double-stranded RNA, mediates suppression of the host translation machinery as a strategy to limit viral replication. Non-translating mRNAs rapidly condensate by phase separation into cytosolic stress granules, together with numerous...

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PMID: 32899736
DOI: 10.3390/v12090984

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