Article

Taurine can restrict mtdsRNA mediated pyroptosis by enhancing mitophagy in nucleus pulposus cells

2025-04-15

Abstract excerpt

<title>Abstract</title> <p>Mitochondrial double-stranded RNA (mtdsRNA), a long-stranded RNA molecule generated by bidirectional transcription of the circular mitochondrial genome, can trigger the type 1 interferon response by activating pattern recognition receptors in the cytoplasm during mitochondrial dysfunction. However, its regulatory and pathogenic mechanisms in intervertebral disc degeneration are poorly u...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0ab8344b-6431-5cc9-a24d-6b27b5fe7d76
DOI: 10.21203/rs.3.rs-5630037/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Taurine can restrict mtdsRNA mediated pyroptosis by enhancing mitophagy in nucleus pulposus cellsDOI 10.21203/rs.3.rs-5630037/v1Read

CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axisSemantic proximity Read

Roles of circular RNAs in the pathogenesis of intervertebral disc degeneration (Review)Semantic proximity Read

Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A ReviewSemantic proximity Read

Stress Granules Buffers Inflammation by Restricting dsRNA-led Mitochondrial FragmentationSemantic proximity Read

Circular RNAs in Intervertebral Disc Degeneration: An Updated ReviewSemantic proximity Read

Emerging role of circular RNA in intervertebral disc degeneration: Knowns and unknowns (Review).Semantic proximity Read

Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosisSemantic proximity Read

The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degenerationSemantic proximity Read

Circular RNAs in nucleus pulposus cell function and intervertebral disc degenerationSemantic proximity Read

Profiling and bioinformatics analysis of differentially expressed circular RNAs in human intervertebral disc degenerationSemantic proximity Read

miR-188-5p delays intervertebral disc degeneration by mediating P4HB to regulate ferroptosis in nucleus pulposus cellsSemantic proximity Read

Parkinson’s genes orchestrate pyroptosis through selective trafficking of mtDNA to leaky lysosomesSemantic proximity Read