Article

Mitochondria-derived dsRNA-induced stress granules promote IRF3-mediated fibrotic responses

2025-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Nucleic acid-induced activation of the anti-viral transcription factor interferon regulatory factor 3 (IRF3) promotes transforming growth factor-beta (TGFβ)-induced fibrotic responses of hepatic stellate cells in vitro . Herein, we identified molecular mechanisms underlying TGFβ-induced IRF3 activation. Gene silencing of IRF3 with short interfering RNA (siRNA) in LX2 human hepatic stellate cel...

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Literature Corpus work: 1a01db9a-0686-5500-b072-63895392d9b2
DOI: 10.1101/2025.05.14.654103

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