Article

The phosphorylation status of LRRK2 at the S910/S935 cluster determines its sensitivity to activation by RAB29

2026-05-26

Abstract excerpt

Leucine-Rich Repeat Kinase 2 (LRRK2) is a signaling molecule involved in Parkinson’s disease pathomechanisms. In disease, the LRRK2 protein displays both a toxic gain of kinase function and a loss of phosphorylation at heterophosphosites found in an extended loop of the LRR domain. RAB GTPases, such as RAB29, have been identified as upstream activators of LRRK2. Indeed, co-expression of LRRK2 with RAB29 induces a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a28454f5-4924-595c-84b3-e833822ce093
DOI: 10.64898/2026.05.22.727151

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The phosphorylation status of LRRK2 at the S910/S935 cluster determines its sensitivity to activation by RAB29DOI 10.64898/2026.05.22.727151Read

Phosphorylation of Rab29 at Ser185 regulates its localization and role in the lysosomal stress response in concert with LRRK2.Semantic proximity Read

LRRK2 Phosphorylation: Behind the Scenes.Semantic proximity Read

LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal toxicity via phosphorylation within its lipid-sensing ALPS2 motifSemantic proximity Read

LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner.Semantic proximity Read

LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same.Semantic proximity Read

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.Semantic proximity Read

Selectivity profiles and substrate recognition of Rab phosphorylating kinasesSemantic proximity Read

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration.Semantic proximity Read

Elucidating the molecular interplay between LRRK2 and Rab GTPasesSemantic proximity Read

Parkinson’s disease-associated LRRK2 risk variant, G2385R, enhances Rab substrate phosphorylation and impairs neuronal integritySemantic proximity Read

Leucine-Rich Repeat Kinases.Semantic proximity Read

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPasesSemantic proximity Read