Article

LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal toxicity via phosphorylation within its lipid-sensing ALPS2 motif

2026-01-13

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 ( LRRK2 ) gene cause late-onset, autosomal dominant Parkinson’s disease (PD). LRRK2 encodes a multi-domain protein containing a Roc GTPase domain and a serine/threonine-directed protein kinase domain, with PD-linked mutations known to enhance LRRK2 kinase activity and neuronal toxicity. Our previous studies identified the Golgi protein, ADP-Ribosylation Factor GTPas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e572aa9a-2777-5c4c-b492-e87a5ab25476
DOI: 10.64898/2026.01.12.699049

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal toxicity via phosphorylation within its lipid-sensing ALPS2 motifDOI 10.64898/2026.01.12.699049Read

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1.Semantic proximity Read

LRRK2 regulates AP2M1 phosphorylation cycles to mediate endocytosis and dopaminergic neurodegenerationSemantic proximity Read

Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson’s Disease: Comparative Analysis of G2019S and I1371V VariantsSemantic proximity Read

Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson's Disease: Comparative Analysis of G2019S and I1371V Variants.Semantic proximity Read

ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2.Semantic proximity Read

Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration.Semantic proximity Read

Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.Semantic proximity Read

LRRK2 recruitment, activity, and function in organelles.Semantic proximity Read

Leucine-rich repeat kinase 2 (LRRK2): balancing cellular homeostasis and Parkinson's disease (PD) pathogenesis.Semantic proximity Read

The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions.Semantic proximity Read

LRRK2 at the interface of autophagosomes, endosomes and lysosomes.Semantic proximity Read

Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphology.Semantic proximity Read