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Article

Phosphorylation of Rab29 at Ser185 regulates its localization and role in the lysosomal stress response in concert with LRRK2.

Journal of cell science - 15 Jul 2023

Komori Tadayuki, Kuwahara Tomoki, Fujimoto Tetta, Sakurai Maria, Koyama-Honda Ikuko, Fukuda Mitsunori, Iwatsubo Takeshi

Abstract excerpt

Rab proteins are small GTPases that regulate a myriad of intracellular membrane trafficking events. Rab29 is one of the Rab proteins phosphorylated by leucine-rich repeat kinase 2 (LRRK2), a Parkinson's disease-associated kinase. Recent studies suggest that Rab29 regulates LRRK2, whereas the mechanism by which Rab29 is regulated remained unclear. Here, we report a novel phosphorylation in Rab29 that is not...

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Identifiers

PMID: 37365944
DOI: 10.1242/jcs.261003
PMCID: PMC10399995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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