Parkinson’s disease-associated LRRK2 risk variant, G2385R, enhances Rab substrate phosphorylation and impairs neuronal integrity

Abstract excerpt

Mutations in the LRRK2 gene are the most frequent cause of familial Parkinson’s disease (PD) whereas common variants are associated with an increased risk for sporadic PD. LRRK2 encodes a multi-domain protein displaying two functional enzymatic activities: GTPase and kinase. Familial LRRK2 mutations have been linked to alterations in its GTPase and kinase activities, elevated substrate phosphorylation, as well...

Topics

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• Cell Membrane
• Cholesterol
• Dopamine
• Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
• Mutation
• Parkinson Disease
• Phosphorylation
• rab GTP-Binding Proteins

Identifiers and source

Literature Corpus work

27e7dece-cbf3-5dab-99d1-031d17651b8b

DOI

10.64898/2026.04.23.720426