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Article

Selectivity profiles and substrate recognition of Rab phosphorylating kinases

2025-04-10

Abstract excerpt

The Rab GTPase switch-2 region is a hotspot for post-translational modifications. Its phosphorylation can determine whether individuals develop Parkinson’s disease or not. Other modifications of the same region are catalysed by enzymes from bacterial pathogens when they infect human cells. Here, we profiled a set of kinases including LRRK1, LRRK2, DYRK1A, MST1, and TBK1 for their capability of phosphorylating Rab...

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Identifiers and source

Literature Corpus work
bfddf9ab-5b23-5958-8496-46625ce5aa32
DOI
10.1101/2025.04.09.647999
Open publication

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Selectivity profiles and substrate recognition of Rab phosphorylating kinasesDOI 10.1101/2025.04.09.647999
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