Article
LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner.
Cell death & disease - 15 Jul 2023
Kania Elżbieta, Long Jaclyn S, McEwan David G, Welkenhuyzen Kirsten, La Rovere Rita, Luyten Tomas, Halpin John, Lobbestael Evy, Baekelandt Veerle, Bultynck Geert, Ryan Kevin M, Parys Jan B
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson's disease (PD), with growing importance also for Crohn's disease and cancer. LRRK2 is a large and complex protein possessing both GTPase and kinase activity. Moreover, LRRK2 activity and function can be influenced by its phosphorylation status. In this regard, many LRRK2 PD-associated mutants display...
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