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Article

LRRK2 Phosphorylation: Behind the Scenes.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry - 1 Oct 2018

De Wit Tina, Baekelandt Veerle, Lobbestael Evy

Abstract excerpt

Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are known today as the most common genetic cause of Parkinson's disease (PD). LRRK2 is a large protein that is hypothesized to regulate other proteins as a scaffold in downstream signaling pathways. This is supported by the multiple domain composition of LRRK2 with several protein-protein interaction domains combined with kinase and GTPase...

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PMID: 29385885
DOI: 10.1177/1073858418756309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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