Article
LRRK2 Phosphorylation: Behind the Scenes.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry - 1 Oct 2018
De Wit Tina, Baekelandt Veerle, Lobbestael Evy
Abstract excerpt
Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are known today as the most common genetic cause of Parkinson's disease (PD). LRRK2 is a large protein that is hypothesized to regulate other proteins as a scaffold in downstream signaling pathways. This is supported by the multiple domain composition of LRRK2 with several protein-protein interaction domains combined with kinase and GTPase...
Topics
- Animals
- Enzyme Inhibitors
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mutation
- Parkinson Disease
- Phosphorylation
- Signal Transduction