Article
LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.
Human molecular genetics - 15 Jan 2018
Liu Zhiyong, Bryant Nicole, Kumaran Ravindran, Beilina Alexandra, Abeliovich Asa, Cookson Mark R, West Andrew B
Abstract excerpt
Human genetic studies implicate LRRK2 and RAB7L1 in susceptibility to Parkinson disease (PD). These two genes function in the same pathway, as knockout of Rab7L1 results in phenotypes similar to LRRK2 knockout, and studies in cells and model organisms demonstrate LRRK2 and Rab7L1 interact in the endolysosomal system. Recently, a subset of Rab proteins have been identified as LRRK2 kinase substrates. Herein, we...
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