Article

Single cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2R47H Alzheimer’s risk gene mutation

2023-12-07

Abstract excerpt

<title>Abstract</title><bold>INTRODUCTION</bold>The R47H missense mutation of the TREM2 gene is a strong risk factor for development of Alzheimer’s Disease. We investigate cell-type-specific spatial transcriptomic changes induced by the<italic>Trem2</italic>R47Hmutation to determine the impacts of this mutation on transcriptional dysregulation.<bold>METHODS</bold>We profiled 15 mouse brain sections c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 34e97c8a-51f9-59ce-8825-3c897abff757
DOI: 10.21203/rs.3.rs-3656139/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2R47H Alzheimer’s risk gene mutationDOI 10.21203/rs.3.rs-3656139/v1Read

Single-cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2R47H Alzheimer's risk gene mutation.Semantic proximity Read

Single-cell Spatial Transcriptional Profiling Uncovers Heterogeneous Cellular Responses to Pathogenic Tau in a Mouse Model of NeurodegenerationSemantic proximity Read

Spatial Multi-Omics Workflow and Analytical Guidelines for Alzheimer’s NeuropathologySemantic proximity Read

Single-cell Spatial Transcriptomics Reveals Disease-specific Microenvironmental Niches in Neurodegeneration and COVID-19Semantic proximity Read

Super-resolved spatial transcriptomics reveals early hippocampal RNA localization changes in a mouse model of Alzheimer’s diseaseSemantic proximity Read

Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult miceSemantic proximity Read

The TREM2-R47H Variant Drives Alzheimer’s-Relevant Alterations in Forebrain Organoids Beyond Microglial PopulationsSemantic proximity Read

A landscape of the genetic and cellular heterogeneity in Alzheimer diseaseSemantic proximity Read

Integrating spatial transcriptomics and snRNA-seq data enhances differential gene expression analysis results of AD-related phenotypesSemantic proximity Read

Trem2 R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to Trem2 deficiency in aged App NL-F knock-in miceSemantic proximity Read

AD-linked R47H- TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humansSemantic proximity Read

Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice.Semantic proximity Read