Article

Multimodal spatial transcriptomics determines repeat expansion, huntingtin aggregation, and selective cortical neuron loss in Huntington’s Disease

2025-12-27

Abstract excerpt

<h4>ABSTRACT</h4> Huntington’s disease (HD) is caused by CAG expansion in HTT , yet how somatic repeat instability and huntingtin aggregation relate to selective cell loss in the human brain remains unclear. We have developed a multimodal spatial transcriptomics approach that enables defining transcriptional programs with subcellular resolution, somatic CAG repeat lengths, and six other pathology marks including...

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Literature Corpus work: e5a8a121-fe64-545d-9fe0-6fb2feab4e7c
DOI: 10.64898/2025.12.26.696622

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