Article

Tau polarizes an aging transcriptional signature to excitatory neurons and glia

2022-11-16

Abstract excerpt

<h4>Summary</h4> Aging is a major risk factor for Alzheimer’s disease (AD), and cell-type vulnerability underlies its characteristic clinical manifestations. We have performed longitudinal, single-cell RNA-sequencing in Drosophila with pan-neuronal expression of human tau, which forms AD neurofibrillary tangle pathology. Whereas tau- and aging-induced gene expression strongly overlap (93%), they differ in the af...

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Literature Corpus work: fc1a6f61-12f5-5d9c-850d-060c125fdfe6
DOI: 10.1101/2022.11.14.516410

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