Article

Human brain single nucleus cell type enrichments in neurodegenerative diseases

2023-11-15

Abstract excerpt

<title>Abstract</title> <p>Background: Single-cell RNA sequencing has opened a window into clarifying the complex underpinnings of disease, particularly in quantifying the relevance of tissue- and cell-type-specific gene expression. <h4>Methods:</h4> To identify the cell types and genes important to therapeutic target development across the neurodegenerative disease spectrum, we leveraged genome-wide association...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 752e31d6-1b68-5186-8a15-d0fa0541c329
DOI: 10.21203/rs.3.rs-3390225/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human brain single nucleus cell type enrichments in neurodegenerative diseasesDOI 10.21203/rs.3.rs-3390225/v1Read

Human brain single nucleus cell type enrichments in neurodegenerative diseasesSemantic proximity Read

A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation.Semantic proximity Read

Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomicsSemantic proximity Read

Single-cell transcriptomics analysis of cellular heterogeneity and immune mechanisms in neurodegenerative diseasesSemantic proximity Read

A single cell brain atlas in human Alzheimer’s diseaseSemantic proximity Read

Cell type-specific associations with Alzheimer’s Disease conserved across racial and ethnic groupsSemantic proximity Read

Single-cell atlas of transcriptomic vulnerability across multiple neurodegenerative and neuropsychiatric diseasesSemantic proximity Read

Single-cell RNA sequencing analysis of human Alzheimer’s disease brain samples reveals neuronal and glial specific cells differential expressionSemantic proximity Read

Single Cell Landscape of Sex-specific Drivers of Alzheimer’s DiseaseSemantic proximity Read

A global view of aging and Alzheimer’s pathogenesis-associated cell population dynamics and molecular signatures in the human and mouse brainsSemantic proximity Read

Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditionsSemantic proximity Read

Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseasesSemantic proximity Read