Article

Super-resolved spatial transcriptomics reveals early hippocampal RNA localization changes in a mouse model of Alzheimer’s disease

2025-09-26

Abstract excerpt

<h4>Summary</h4> Cell-type-specific changes in gene expression and RNA localization are hallmarks of Alzheimer’s disease (AD) and other neurodegenerative disorders, yet spatial dysregulation in early disease stages remains poorly defined. Here, we applied Expansion Sequencing (ExSeq) to map the spatial distribution of 101 genes at super-resolution in the hippocampus of 4-week-old 5xFAD and wild-type (WT) mice, pr...

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Literature Corpus work: 53371574-4f34-5cc7-962a-62d9e5237abd
DOI: 10.1101/2025.09.24.678295

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