Article

Toward Precision Molecular Surgery: Robust, Selective Induction of Microhomology-mediated End Joining <i>in vivo</i>

2018-03-28

Abstract excerpt

One key problem in precision genome editing is the resultant unpredictable plurality of sequence outcomes at the site of targeted DNA double-strand breaks (DSBs). This is due to the typical activation of the versatile Non-homologous End Joining (NHEJ) pathway. Such unpredictability limits the utility of somatic gene editing for applications including gene therapy and functional genomics. For germline editing work,...

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Literature Corpus work: a2799661-61cd-5f51-bc34-3cbf105947ef
DOI: 10.1101/291187

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