Article

Reading frame restoration at the EYS locus, and allele-specific chromosome removal after Cas9 cleavage in human embryos

2020-06-18

Abstract excerpt

<h4>Summary</h4> The correction of disease-causing mutations in human embryos could reduce the burden of inherited genetic disorders in the fetus and newborn, and improve the efficiency of fertility treatments for couples with disease-causing mutations in lieu of embryo selection. Here we evaluate the repair outcomes of a Cas9-induced double-strand break (DSB) introduced on the paternal chromosome at the EYS loc...

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Literature Corpus work: 482b8f3c-7c1f-5daa-b7f0-5493cf6d1f53
DOI: 10.1101/2020.06.17.149237

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