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Article

Robust activation of microhomology-mediated end joining for precision gene editing applications.

PLoS genetics - 1 Sept 2018

Ata Hirotaka, Ekstrom Thomas L, Martínez-Gálvez Gabriel, Mann Carla M, Dvornikov Alexey V, Schaefbauer Kyle J, Ma Alvin C, Dobbs Drena, Clark Karl J, Ekker Stephen C

Abstract excerpt

One key problem in precision genome editing is the unpredictable plurality of sequence outcomes at the site of targeted DNA double stranded breaks (DSBs). This is due to the typical activation of the versatile Non-homologous End Joining (NHEJ) pathway. Such unpredictability limits the utility of somatic gene editing for applications including gene therapy and functional genomics. For germline editing work, the...

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Share to DNA Breaks, Double-Stranded
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30208061
DOI: 10.1371/journal.pgen.1007652
PMCID: PMC6152997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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