Article

Molecular characterization of the archaic HLA-B*73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2

2024-11-28

Abstract excerpt

HLA class I alleles of archaic origin may have been retained in modern humans because they provide immunity against diseases to which archaic humans had evolved resistance. According to this model, archaic introgressed alleles were somehow distinct from those that evolved in African populations. Here we show that HLA-B*73:01, a rare allotype with putative archaic origins, has a relatively rare peptide binding moti...

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Literature Corpus work: a2784db8-67e0-52c8-96d9-de7ecb694832
DOI: 10.1101/2024.11.25.625330

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