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Article

Like Wings of a Bird: Functional Divergence and Complementarity between HLA-A and HLA-B Molecules.

Molecular biology and evolution - 13 Apr 2021

Di Da, Nunes Jose Manuel, Jiang Wei, Sanchez-Mazas Alicia

Abstract excerpt

Human leukocyte antigen (HLA) genes are among the most polymorphic of our genome, as a likely consequence of balancing selection related to their central role in adaptive immunity. HLA-A and HLA-B genes were recently suggested to evolve through a model of joint divergent asymmetric selection conferring all human populations, including those with severe loss of diversity, an equivalent immune potential. However,...

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Identifiers

PMID: 33320202
DOI: 10.1093/molbev/msaa325
PMCID: PMC8355449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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