Article
Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles.
PLoS genetics - 1 Jun 2017
Robinson James, Guethlein Lisbeth A, Cereb Nezih, Yang Soo Young, Norman Paul J, Marsh Steven G E, Parham Peter
Abstract excerpt
HLA class I glycoproteins contain the functional sites that bind peptide antigens and engage lymphocyte receptors. Recently, clinical application of sequence-based HLA typing has uncovered an unprecedented number of novel HLA class I alleles. Here we define the nature and extent of the variation in 3,489 HLA-A, 4,356 HLA-B and 3,111 HLA-C alleles. This analysis required development of suites of methods, having...
Topics
- Alleles
- DNA Mutational Analysis
- Genetics, Population
- Germ-Line Mutation
- HLA-A Antigens
- HLA-B Antigens
- HLA-C Antigens
- Histocompatibility Testing
- Humans
- Phylogeny
- Point Mutation