Article
Mutational and structural analysis of KIR3DL1 reveals a lineage-defining allotypic dimorphism that impacts both HLA and peptide sensitivity.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2014
O'Connor Geraldine M, Vivian Julian P, Widjaja Jacqueline M, Bridgeman John S, Gostick Emma, Lafont Bernard A P, Anderson Stephen K, Price David A, Brooks Andrew G, Rossjohn Jamie, McVicar Daniel W
Abstract excerpt
Killer Ig-like receptors (KIRs) control the activation of human NK cells via interactions with peptide-laden HLAs. KIR3DL1 is a highly polymorphic inhibitory receptor that recognizes a diverse array of HLA molecules expressing the Bw4 epitope, a group with multiple polymorphisms incorporating variants within the Bw4 motif. Genetic studies suggest that KIR3DL1 variation has functional significance in several...
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