Article
Molecular characterization of the archaic HLA-B∗73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2.
The Journal of biological chemistry - 1 Sept 2025
Ross Philipp, Hilton Hugo G, Lodwick Jane, Slezak Tomasz, Guethlein Lisbeth A, McMurtrey Curtis P, Han Alex S, Nielsen Morten, Yong Daniel, Dulberger Charles L, Nolan Kristof T, Roy Sobhan, Castro Caitlin D, Hildebrand William H, Zhao Minglei, Kossiakoff Anthony, Parham Peter, Adams Erin J
Abstract excerpt
HLA class I alleles of archaic origin may have been retained in modern humans because they provide immunity against diseases to which archaic humans had evolved resistance. According to this model, archaic introgressed alleles were somehow distinct from those that evolved in African populations. Here, we show that HLA-B∗73:01, a rare allotype with putative archaic origins, has a relatively rare peptide binding...
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