Article
Ancient haplotypes of the HLA Class II region.
Genome research - 1 Sept 2005
Raymond Christopher K, Kas Arnold, Paddock Marcia, Qiu Ruolan, Zhou Yang, Subramanian Sandhya, Chang Jean, Palmieri Anthony, Haugen Eric, Kaul Rajinder, Olson Maynard V
Abstract excerpt
Allelic variation in codons that specify amino acids that line the peptide-binding pockets of HLA's Class II antigen-presenting proteins is superimposed on strikingly few deeply diverged haplotypes. These haplotypes appear to have been evolving almost independently for tens of millions of years. By complete resequencing of 20 haplotypes across the approximately 100-kbp region that spans the HLA-DQA1, -DQB1, and...
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