Article
Variable NK cell receptors exemplified by human KIR3DL1/S1.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2011
Parham Peter, Norman Paul J, Abi-Rached Laurent, Guethlein Lisbeth A
Abstract excerpt
Variegated expression of variable NK cell receptors for polymorphic MHC class I broadens the range of an individual's NK cell response and the capacity for populations and species to survive disease epidemics and population bottlenecks. On evolutionary time scales, this component of immunity is exceptionally dynamic, unstable, and short-lived, being dependent on coevolution of ligands and receptors subject to...
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