An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania.

doi:10.1016/j.cell.2024.10.005

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Article

An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania.

Cell - 27 Nov 2024

Loh Liyen, Saunders Philippa M, Faoro Camilla, Font-Porterias Neus, Nemat-Gorgani Neda, Harrison Genelle F, Sadeeq Suraju, Hensen Luca, Wong Shu Cheng, Widjaja Jacqueline, Clemens E Bridie, Zhu Shiying, Kichula Katherine M, Tao Sudan, Zhu Faming, Montero-Martin Gonzalo, Fernandez-Vina Marcelo, Guethlein Lisbeth A, Vivian Julian P, Davies Jane, Mentzer Alexander J, Oppenheimer Stephen J, Pomat William, Ioannidis Alexander G, Barberena-Jonas Carmina, Moreno-Estrada Andrés, Miller Adrian, Parham Peter, Rossjohn Jamie, Tong Steven Y C, Kedzierska Katherine, Brooks Andrew G, Norman Paul J

Abstract excerpt

Genetic variation in host immunity impacts the disproportionate burden of infectious diseases that can be experienced by First Nations peoples. Polymorphic human leukocyte antigen (HLA) class I and killer cell immunoglobulin-like receptors (KIRs) are key regulators of natural killer (NK) cells, which mediate early infection control. How this variation impacts their responses across populations is unclear. We show...

Topics

Humans
Killer Cells, Natural
Oceania
Alleles
Receptors, KIR3DL1
Australia
Selection, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histocompatibility Antigens Class I

HLA-A24 Antigen

Genetic Variation

Indigenous Peoples

Source

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Identifiers

PMID: 39476840
DOI: 10.1016/j.cell.2024.10.005
PMCID: PMC11606752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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