An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania.

doi:10.1016/j.cell.2024.10.005

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Article

An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania.

Cell - 27 Nov 2024

Loh Liyen, Saunders Philippa M, Faoro Camilla, Font-Porterias Neus, Nemat-Gorgani Neda, Harrison Genelle F, Sadeeq Suraju, Hensen Luca, Wong Shu Cheng, Widjaja Jacqueline, Clemens E Bridie, Zhu Shiying, Kichula Katherine M, Tao Sudan, Zhu Faming, Montero-Martin Gonzalo, Fernandez-Vina Marcelo, Guethlein Lisbeth A, Vivian Julian P, Davies Jane, Mentzer Alexander J, Oppenheimer Stephen J, Pomat William, Ioannidis Alexander G, Barberena-Jonas Carmina, Moreno-Estrada Andrés, Miller Adrian, Parham Peter, Rossjohn Jamie, Tong Steven Y C, Kedzierska Katherine, Brooks Andrew G, Norman Paul J

Abstract excerpt

Genetic variation in host immunity impacts the disproportionate burden of infectious diseases that can be experienced by First Nations peoples. Polymorphic human leukocyte antigen (HLA) class I and killer cell immunoglobulin-like receptors (KIRs) are key regulators of natural killer (NK) cells, which mediate early infection control. How this variation impacts their responses across populations is unclear. We show...

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PMID: 39476840
DOI: 10.1016/j.cell.2024.10.005
PMCID: PMC11606752

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