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Article

The shaping of modern human immune systems by multiregional admixture with archaic humans.

Science (New York, N.Y.) - 7 Oct 2011

Abi-Rached Laurent, Jobin Matthew J, Kulkarni Subhash, McWhinnie Alasdair, Dalva Klara, Gragert Loren, Babrzadeh Farbod, Gharizadeh Baback, Luo Ma, Plummer Francis A, Kimani Joshua, Carrington Mary, Middleton Derek, Rajalingam Raja, Beksac Meral, Marsh Steven G E, Maiers Martin, Guethlein Lisbeth A, Tavoularis Sofia, Little Ann-Margaret, Green Richard E, Norman Paul J, Parham Peter

Abstract excerpt

Whole genome comparisons identified introgression from archaic to modern humans. Our analysis of highly polymorphic human leukocyte antigen (HLA) class I, vital immune system components subject to strong balancing selection, shows how modern humans acquired the HLA-B*73 allele in west Asia throug...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21868630
DOI: 10.1126/science.1209202
PMCID: PMC3677943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21868630-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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