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Article

Exceptional diversity of KIR and HLA class I in Egypt.

HLA - 1 Jan 2024

Montero-Martin Gonzalo, Kichula Katherine M, Misra Maneesh K, de Brito Vargas Luciana, Marin Wesley M, Hollenbach Jill A, Fernández-Viña Marcelo A, Elfishawi Sally, Norman Paul J

Abstract excerpt

Genetically determined variation of killer cell immunoglobulin like receptors (KIR) and their HLA class I ligands affects multiple aspects of human health. Their extreme diversity is generated through complex interplay of natural selection for pathogen resistance and reproductive health, combined with demographic structure and dispersal. Despite significant importance to multiple health conditions of differential...

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Identifiers

PMID: 37528739
DOI: 10.1111/tan.15177
PMCID: PMC11068459

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