Article
Identification of sequence variants influencing immunoglobulin levels.
Nature genetics - 1 Aug 2017
Jonsson Stefan, Sveinbjornsson Gardar, de Lapuente Portilla Aitzkoa Lopez, Swaminathan Bhairavi, Plomp Rosina, Dekkers Gillian, Ajore Ram, Ali Mina, Bentlage Arthur E H, Elmér Evelina, Eyjolfsson Gudmundur I, Gudjonsson Sigurjon A, Gullberg Urban, Gylfason Arnaldur, Halldorsson Bjarni V, Hansson Markus, Holm Hilma, Johansson Åsa, Johnsson Ellinor, Jonasdottir Aslaug, Ludviksson Bjorn R, Oddsson Asmundur, Olafsson Isleifur, Olafsson Sigurgeir, Sigurdardottir Olof, Sigurdsson Asgeir, Stefansdottir Lilja, Masson Gisli, Sulem Patrick, Wuhrer Manfred, Wihlborg Anna-Karin, Thorleifsson Gudmar, Gudbjartsson Daniel F, Thorsteinsdottir Unnur, Vidarsson Gestur, Jonsdottir Ingileif, Nilsson Björn, Stefansson Kari
Abstract excerpt
Immunoglobulins are the effector molecules of the adaptive humoral immune system. In a genome-wide association study of 19,219 individuals, we found 38 new variants and replicated 5 known variants associating with IgA, IgG or IgM levels or with composite immunoglobulin traits, accounted for by 32 loci. Variants at these loci also affect the risk of autoimmune diseases and blood malignancies and influence blood...
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