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The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations

2025-02-12

Abstract excerpt

The human immunoglobulin heavy chain constant (IGHC) domain of antibodies (Ab) is responsible for effector functions critical to immunity. This domain is encoded by genes in the IGHC locus, where descriptions of genomic diversity remain incomplete. We utilized long-read sequencing to build an IGHC haplotype/variant catalog from 105 individuals of diverse ancestry. We discovered uncharacterized single nucleotide va...

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Literature Corpus work
e42ca185-256f-53a1-b1a1-343065fcb84e
DOI
10.1101/2025.02.12.634878
Open publication

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The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populationsDOI 10.1101/2025.02.12.634878
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