Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Population-specific diversity of the immunoglobulin constant heavy G chain (IGHG) genes.

Genes and immunity - 1 Dec 2021

Bashirova Arman A, Zheng Wanjing, Akdag Marjan, Augusto Danillo G, Vince Nicolas, Dong Krista L, O'hUigin Colm, Carrington Mary

Abstract excerpt

Human immunoglobulin G (IgG) molecules, IgG1, IgG2 and IgG3, exhibit substantial inter-individual variation in their constant heavy chain regions, as discovered by serological methods. This polymorphism is encoded by the IGHG1, IGHG2, and IGHG3 genes and may influence antibody function. We sequenced the coding fragments of these genes in 95 European Americans, 94 African Americans, and 94 Black South Africans....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Blood groups and transfusion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Glycosylation and Glycoproteins Research

Share to Immunoglobulin G

Share to Immunoglobulin Heavy Chains

Share to Monoclonal and Polyclonal Antibodies Research

Share to Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 34864821
DOI: 10.1038/s41435-021-00156-2
PMCID: PMC8674132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Population-specific diversity of the immunoglobulin constant heavy G chain (IGHG) genes.PMID 34864821Read ↗

Unveiling the Diversity of Immunoglobulin Heavy Constant Gamma (IGHG) Gene Segments in Brazilian Populations Reveals 28 Novel Alleles and Evidence of Gene Conversion and Natural SelectionSemantic proximity Read ↗

The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populationsSemantic proximity Read ↗

The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations.Semantic proximity Read ↗

Identification of IgG1 and IgG3 Allotypes by PCR and Sanger Sequencing.Semantic proximity Read ↗

Sequence variants influencing the regulation of serum IgG subclass levels.Semantic proximity Read ↗

The Individual and Population Genetics of Antibody Immunity.Semantic proximity Read ↗

Population-scale immunoglobulin genetics resolves the human B-cell systemSemantic proximity Read ↗

Novel polymorphic and copy number diversity in the antibody IGH locus of South African individuals.Semantic proximity Read ↗

Human immunoglobulin constant heavy G chain (IGHG) (Fcγ) (GM) genes, defining innate variants of IgG molecules and B cells, have impact on disease and therapy.Semantic proximity Read ↗

An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms.Semantic proximity Read ↗

Ultra-high-throughput IGH genotyping of 25 global populations reveals population-biased allelic diversity and homozygous V and D gene deletions.Semantic proximity Read ↗

Discovery of 10,828 new putative human immunoglobulin heavy chain IGHV variantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.