Article
Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics
2019-11-15
Abstract excerpt
To define the growing significance of cellular targets of cancer drugs, we examined the fitness dependency of cellular targets or effectors of cancer drug targets across human cancer cells from 19 cancer types. We observed that the deletion of 35 out of 47 cellular mediators or targets of oncology drugs did not result in the expected loss of cell fitness in appropriate cancer types for which drugs targeting or uti...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- a1efbe25-4d4c-5713-b0e7-d3a3450dde10
- DOI
- 10.1101/840975