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Article

A comprehensive map of molecular drug targets.

Nature reviews. Drug discovery - 1 Jan 2017

Santos Rita, Ursu Oleg, Gaulton Anna, Bento A Patrícia, Donadi Ramesh S, Bologa Cristian G, Karlsson Anneli, Al-Lazikani Bissan, Hersey Anne, Oprea Tudor I, Overington John P

Abstract excerpt

The success of mechanism-based drug discovery depends on the definition of the drug target. This definition becomes even more important as we try to link drug response to genetic variation, understand stratified clinical efficacy and safety, rationalize the differences between drugs in the same therapeutic class and predict drug utility in patient subgroups. However, drug targets are often poorly defined in the...

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Identifiers

PMID: 27910877
DOI: 10.1038/nrd.2016.230
PMCID: PMC6314433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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