Article

The biological essence of synthetic lethality: Bringing new opportunities for cancer therapy

2024-03-01

Abstract excerpt

Abstract Synthetic lethality (SL), a genetic concept, has revolutionized the development of antitumor therapies by providing avenues to target previously “undruggable” targets with enhanced specificity for tumor cells over normal tissue. The principles of SL have expanded beyond genetic definitions to encompass biological functions, including genome stability, cell cycle regulation, cell death mechanisms, cellular...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fe202e07-bbd4-56c6-82b0-194e996be1dd
DOI: 10.1002/mog2.70

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The biological essence of synthetic lethality: Bringing new opportunities for cancer therapyDOI 10.1002/mog2.70Read

Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation.Semantic proximity Read

The power and the promise of synthetic lethality for clinical application in cancer treatmentSemantic proximity Read

Leveraging microenvironmental synthetic lethalities to treat cancerSemantic proximity Read

[Synthetic lethality as a new concept for the treatment of cancer].Semantic proximity Read

Development of synthetic lethality in cancer: molecular and cellular classification.Semantic proximity Read

Synthetic Lethality in Cancer Therapeutics: The Next GenerationSemantic proximity Read

Synthetic lethality on drug discovery: an update on cancer therapy.Semantic proximity Read

A Methodological Workflow to Analyze Synthetic Lethality and Drug Synergism in Cancer Cells.Semantic proximity Read

Synthetic lethality: exploiting the addiction of cancer to DNA repair.Semantic proximity Read

Re-defining synthetic lethality by phenotypic profiling for precision oncology.Semantic proximity Read

Embracing synthetic lethality of novel anticancer therapies.Semantic proximity Read

Synthetic lethality-based targets for discovery of new cancer therapeutics.Semantic proximity Read