Higher order synthetic lethals are keys to minimize cancer treatment effects on non-tumor cells

Abstract excerpt

Metabolic rewiring in cancer cells facilitates the provision of essential precursors for the unbridled growth of tumors. Exploring these cancer-specific metabolic changes offers potential selective therapeutic strategies. However, targeting a single essential gene in cancer treatment often faces challenges, including resistance, lack of targetable oncogenes, and potential harm to non-tumor cells. Attacking multipl...

Topics

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• CRISPR and Genetic Engineering
• Drug Synergism
• Mutation
• Neoplasms
• PARP inhibition in cancer therapy
• RNA Interference and Gene Delivery
• Synthetic Lethal Mutations
• Workflow

Identifiers and source

Literature Corpus work

fed5b112-3bb8-5538-9964-88e2d92ef04e

DOI

10.1101/2025.01.31.635848