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Article

Functional viability profiles of breast cancer.

Cancer discovery - 1 Aug 2011

Brough Rachel, Frankum Jessica R, Sims David, Mackay Alan, Mendes-Pereira Ana M, Bajrami Ilirjana, Costa-Cabral Sara, Rafiq Rumana, Ahmad Amar S, Cerone Maria Antonietta, Natrajan Rachael, Sharpe Rachel, Shiu Kai-Keen, Wetterskog Daniel, Dedes Konstantine J, Lambros Maryou B, Rawjee Teeara, Linardopoulos Spiros, Reis-Filho Jorge S, Turner Nicholas C, Lord Christopher J, Ashworth Alan

Abstract excerpt

UNLABELLED: The design of targeted therapeutic strategies for cancer has largely been driven by the identification of tumor-specific genetic changes. However, the large number of genetic alterations present in tumor cells means that it is difficult to discriminate between genes that are critical for maintaining the disease state and those that are merely coincidental. Even when critical genes can be identified,...

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Source

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Identifiers

PMID: 21984977
DOI: 10.1158/2159-8290.CD-11-0107
PMCID: PMC3188379

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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