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A Methodological Workflow to Analyze Synthetic Lethality and Drug Synergism in Cancer Cells.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022

Gout Johann, Roger Elodie, Kleger Alexander, Perkhofer Lukas

Abstract excerpt

Current concepts in treating cancer usually neglect individual tumor characteristics such as a given mutational make up. Consequently, a "one-size-fits-all" therapeutic concept may commonly fail in terms of efficacy, evolving drug resistance, and side effects. In times of omics, novel elaborated and personalized approaches emerge for efficiently eradicate cancer cells, while sparing healthy cells. Synthetic...

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PMID: 35867222
DOI: 10.1007/978-1-0716-2513-2_5

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