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Article

Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics.

Cells - 18 Feb 2021

George Bijesh, Pillai P Mukundan, Paul Aswathy Mary, Amjesh Revikumar, Leitzel Kim, Ali Suhail M, Sandiford Oleta, Lipton Allan, Rameshwar Pranela, Hortobagyi Gabriel N, Pillai Madhavan Radhakrishna, Kumar Rakesh

Abstract excerpt

To define the growing significance of cellular targets and/or effectors of cancer drugs, we examined the fitness dependency of cellular targets and effectors of cancer drug targets across human cancer cells from 19 cancer types. We observed that the deletion of 35 out of 47 cellular effectors and/or targets of oncology drugs did not result in the expected loss of cell fitness in appropriate cancer types for which...

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Identifiers

PMID: 33670680
DOI: 10.3390/cells10020433
PMCID: PMC7921985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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