Resolution of <i>in situ</i> inflammation in human lupus nephritis into principal immune cell trajectories

Abstract excerpt

<h4>ABSTRACT</h4> In human lupus nephritis (LuN), tubulointerstitial inflammation (TII) is prognostically more important than glomerular inflammation. However, a comprehensive understanding of both TII complexity and heterogeneity is lacking. Herein, we used high-dimensional confocal microscopy and specialized computer vision techniques to quantify immune cell populations and localize these within normal and dise...

Topics

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• Immune cells in cancer
• Renal Diseases and Glomerulopathies
• Reproductive System and Pregnancy
• Single-cell and spatial transcriptomics
• Systemic Lupus Erythematosus Research
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

a1686c80-a37b-575a-8966-c8fbb8a4da46

DOI

10.1101/2025.02.17.638655