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Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis

7 Nov 2022

Abstract excerpt

Lupus nephritis is a serious complication of systemic lupus erythematosus, mediated by IgG immune complex (IC) deposition in kidneys, with limited treatment options. Kidney macrophages are critical tissue sentinels that express IgG-binding Fcγ receptors (FcγRs), with previous studies identifying prenatally seeded resident macrophages as major IC responders. Using single-cell transcriptomic and spatial analyses in...

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PMID: 36345939
DOI: 10.1172/jci.insight.159751

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