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Childhood-onset lupus nephritis is characterized by complex interactions between kidney stroma and infiltrating immune cells

27 Nov 2024

Abstract excerpt

Children with systemic lupus erythematosus (SLE) are at increased risk of developing kidney disease, termed childhood-onset lupus nephritis (cLN). Single-cell transcriptomics of dissociated kidney tissue has advanced our understanding of LN pathogenesis, but loss of spatial resolution prevents interrogation of in situ cellular interactions. Using a technical advance in spatial transcriptomics, we generated a...

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PMID: 39602512
DOI: 10.1126/scitranslmed.adl1666

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