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Spatial transcriptomics reveals injury-responsive compartments and coordinated immune–fibrotic signaling in ANCA-associated renal vasculitis

2025-09-21

Abstract excerpt

ANCA-associated vasculitis (AAV) often presents with rapidly progressive glomerulonephritis, yet how immune and stromal programmes are organised within kidney tissue remains unclear. We applied spatial transcriptomics to renal cortex biopsies from patients with AAV of varying disease severity and normal-histology controls, generating a spatial map that localizes disease programmes in situ . Four disease-responsiv...

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Literature Corpus work
8b92f7db-7c52-5c90-9740-7f0880f01f81
DOI
10.1101/2025.09.19.677268
Open publication

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Spatial transcriptomics reveals injury-responsive compartments and coordinated immune–fibrotic signaling in ANCA-associated renal vasculitisDOI 10.1101/2025.09.19.677268
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