Back to search

Article

A population-scale atlas of blood and tissue in lupus nephritis

2025-08-14

Abstract excerpt

Lupus nephritis (LN), a severe manifestation of Systemic Lupus Erythematosus (SLE), is a heterogeneous disease driven by diverse immune and tissue cell types. We obtained 538K single-cell and 140K single-nuclear profiles from kidney biopsies of 155 LN patients and 30 pre-implantation transplant biopsy controls, along with 325K single-cell blood profiles overlapping many of these patients. We identified key tissue...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6393e7da-684d-5e2b-8c54-681122c8a83e
DOI
10.1101/2025.08.11.669754
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A population-scale atlas of blood and tissue in lupus nephritisDOI 10.1101/2025.08.11.669754
Deep profiling of lupus nephritis kidneys reveals dynamic changes in myeloid cells associated with disease progressionSemantic proximity
Childhood-onset lupus nephritis is characterized by complex interactions between kidney stroma and infiltrating immune cellsSemantic proximity
Regulatory architecture underlying immune dysregulation reconstructed by single-cell multi-omics in lupus nephritisSemantic proximity
The immune cell landscape in kidneys of lupus nephritis patientsSemantic proximity
Single cell spatial transcriptomic profiling of childhood-onset lupus nephritis reveals complex interactions between kidney stroma and infiltrating immune cellsSemantic proximity
An atlas of healthy and injured cell states and niches in the human kidneySemantic proximity
An atlas of healthy and injured cell states and niches in the human kidneySemantic proximity
Intrarenal myeloid subsets associated with kidney injury are comparable in mice and patients with lupus nephritisSemantic proximity
Spatially resolved human kidney multi-omics single cell atlas highlights the key role of the fibrotic microenvironment in kidney disease progressionSemantic proximity
A protocol for single-cell transcriptomics from cryopreserved renal tissue and urine for the Accelerating Medicine Partnership (AMP) RA/SLE networkSemantic proximity
A transcriptional patient map of systemic lupus erythematosus reveals disease-related multicellular immune programs conserved between blood and kidneySemantic proximity
Resolution of <i>in situ</i> inflammation in human lupus nephritis into principal immune cell trajectoriesSemantic proximity
Select a neighboring publication to make it the new centre.