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Spatial proteomics landscape and immune signature analysis of renal sample of lupus nephritis based on laser-captured microsection

20 Jul 2023

Abstract excerpt

OBJECTIVE: We aimed to reveal a spatial proteomic and immune signature of kidney function regions in lupus nephritis (LN). MATERIAL AND METHODS: The laser capture microdissection (LCM) was used to isolate the glomerulus, tubules, and interstitial of the kidney from paraffin samples. The data-independent acquisition (DIA) method was used to collect proteomics data. The bioinformatic analysis was performed....

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PMID: 37474625
DOI: 10.1007/s00011-023-01767-3

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