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Regulatory architecture underlying immune dysregulation reconstructed by single-cell multi-omics in lupus nephritis

2026-05-07

Abstract excerpt

<h4>Objectives</h4> Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus with heterogeneous clinical outcomes and limited therapeutic options. Although immune dysregulation is central to LN pathogenesis, the underlying cell-type-specific regulatory mechanisms and their genetic determinants remain poorly characterized. <h4>Methods</h4> We generated a single-cell multi-omics atlas of perip...

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Literature Corpus work
4f37fb22-7c98-50de-bc92-1efc003eae5c
DOI
10.64898/2026.05.06.26352515
Open publication

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Regulatory architecture underlying immune dysregulation reconstructed by single-cell multi-omics in lupus nephritisDOI 10.64898/2026.05.06.26352515
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