Article
Multigenerational downregulation of insulin/IGF-1 signaling in adulthood improves lineage survival, reproduction, and fitness in Caenorhabditis elegans supporting the developmental theory of ageing.
Evolution; international journal of organic evolution - 1 Dec 2022
Duxbury Elizabeth M L, Carlsson Hanne, Sales Kris, Sultanova Zahida, Immler Simone, Chapman Tracey, Maklakov Alexei A
Abstract excerpt
Adulthood-only downregulation of insulin/IGF-1 signaling (IIS), an evolutionarily conserved pathway regulating resource allocation between somatic maintenance and reproduction, increases life span without fecundity cost in the nematode, Caenorhabditis elegans. However, long-term multigenerational effects of reduced IIS remain unexplored and are proposed to carry costs for offspring quality. To test this...
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