Article

A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response in human cells

2022-01-18

Abstract excerpt

<h4>ABSTRACT</h4> Helix-destabilizing DNA lesions induced by environmental mutagens such as UV light cause genomic instability by strongly blocking the progression of DNA replication forks (RF). At blocked RF, single-stranded DNA (ssDNA) accumulates and is rapidly bound by Replication Protein A (RPA) complexes. Such stretches of RPA-ssDNA constitute platforms for recruitment/activation of critical factors that pr...

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Literature Corpus work: a0f7bc78-ce1f-520f-9281-dc73c35a32f0
DOI: 10.1101/2022.01.17.476707

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