Article

EXO1-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells

2024-01-23

Abstract excerpt

<h4>ABSTRACT</h4> DNA replication faces challenges from DNA lesions originated from endogenous or exogenous sources of stress, leading to the accumulation of single-stranded DNA (ssDNA) that triggers the activation of the ATR checkpoint response. To complete genome replication in the presence of damaged DNA, cells employ DNA damage tolerance mechanisms that operate not only at stalled replication forks but also a...

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Literature Corpus work: 333888d9-20f6-53fe-82f3-6271fea398f0
DOI: 10.1101/2024.01.22.576613

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